Bone morphogenetic protein-2 （BMP-2） is a kind of bone growth regulator, belonging to protein transforming
growth factor-β（TGF-β） superfamily. BMP-2 protein is involved in hedgehog pathway, TGF-β signaling pathway and
cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMP, which have been proved to be effective in
inducing osteoblast differentiation in many cell types. The active form of BMP-2 can be composed of dimers of two identical
proteins or heterodimers of two related bone morphogenetic proteins.